Courtney Holmes Selected Research

Orthostatic Hypotension (Postural Hypotension)

10/2020	Cardiac sympathetic innervation and vesicular storage in pure autonomic failure.
10/2019	Long-term trends in myocardial sympathetic innervation and function in synucleinopathies.
1/2019	Alpha-Synuclein Deposition Within Sympathetic Noradrenergic Neurons Is Associated With Myocardial Noradrenergic Deficiency in Neurogenic Orthostatic Hypotension.
1/2019	Substantial renal conversion of L-threo-3,4-dihydroxyphenylserine (droxidopa) to norepinephrine in patients with neurogenic orthostatic hypotension.
1/2017	Pure autonomic failure without synucleinopathy.
1/2017	Autoimmunity-associated autonomic failure with sympathetic denervation.
11/2015	Survival in synucleinopathies: A prospective cohort study.
2/2015	Plasma biomarkers of decreased vesicular storage distinguish Parkinson disease with orthostatic hypotension from the parkinsonian form of multiple system atrophy.
12/2012	Temporary elimination of orthostatic hypotension by norepinephrine infusion.
8/2011	Intra-neuronal vesicular uptake of catecholamines is decreased in patients with Lewy body diseases.

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Courtney Holmes Research Topics

Disease

32	Parkinson Disease (Parkinson's Disease) 01/2021 - 08/2002
22	Orthostatic Hypotension (Postural Hypotension) 10/2020 - 06/2003
20	Pure Autonomic Failure 01/2021 - 08/2002
19	Multiple System Atrophy 01/2021 - 08/2002
11	Parkinsonian Disorders (Parkinsonism) 01/2021 - 09/2003
8	Synucleinopathies 01/2021 - 08/2011
4	Lewy Body Disease (Lewy Body Dementia) 01/2017 - 03/2009
4	Hypertension (High Blood Pressure) 02/2016 - 07/2003
4	Dizziness (Lightheadedness) 01/2010 - 08/2002
3	Pheochromocytoma 09/2016 - 06/2004
3	Neurodegenerative Diseases (Neurodegenerative Disease) 09/2015 - 12/2008
3	Orthostatic Intolerance 08/2009 - 01/2003
1	Rare Diseases (Rare Disease) 10/2020
1	Movement Disorders (Movement Disorder) 10/2016
1	Menkes Kinky Hair Syndrome (Menkes Disease) 01/2015
1	dopamine beta hydroxylase deficiency 06/2012
1	Dementia (Dementias) 02/2012
1	Anosmia 01/2010
1	Hypotension (Low Blood Pressure) 08/2009
1	Bradycardia 09/2008
1	Familial Dysautonomia (Riley Day Syndrome) 09/2008
1	Quadriplegia (Spastic Quadriplegia) 01/2008
1	Hypoxia (Hypoxemia) 02/2006
1	Heart Failure 06/2005
1	Depressive Disorder (Melancholia) 06/2005
1	Hyperthermia 06/2005
1	Rhabdomyolysis 06/2005
1	Type 1 Familial Parkinson Disease 04/2004
1	Essential Hypertension 08/2003
1	Neoplasms (Cancer) 07/2003
1	Alzheimer Disease (Alzheimer's Disease) 06/2003
1	Vasovagal Syncope 06/2003
1	Postural Orthostatic Tachycardia Syndrome 06/2003
1	Autonomic Nervous System Diseases (Dysautonomia) 06/2003
1	Syncope (Fainting) 01/2003
1	Diabetic Neuropathies (Diabetic Neuropathy) 12/2002
1	Peripheral Nervous System Diseases (PNS Diseases) 12/2002

Drug/Important Bio-Agent (IBA)

22	Norepinephrine (Noradrenaline)FDA LinkGeneric 01/2021 - 08/2002
14	Dopamine (Intropin)FDA LinkGeneric 12/2020 - 04/2008
11	CatecholaminesIBA 01/2021 - 01/2003
9	hydroxide ionIBA 01/2021 - 06/2003
7	alpha-SynucleinIBA 01/2021 - 04/2004
6	Biomarkers (Surrogate Marker)IBA 10/2019 - 12/2008
4	Proteins (Proteins, Gene)FDA Link 01/2021 - 01/2017
4	TyramineIBA 02/2016 - 09/2008
4	SynucleinsIBA 11/2015 - 04/2004
4	CatecholsIBA 06/2012 - 06/2003
3	Neurotransmitter Agents (Neurotransmitter)IBA 10/2020 - 08/2003
3	3,4-dihydroxyphenylacetaldehydeIBA 09/2016 - 12/2012
3	3,4-dihydroxyphenylglycolIBA 01/2010 - 12/2004
3	Aromatic-L-Amino-Acid DecarboxylasesIBA 12/2004 - 03/2003
2	DroxidopaIBA 01/2019 - 05/2010
2	3,4-Dihydroxyphenylacetic AcidIBA 01/2018 - 10/2016
2	Monoamine Oxidase (MAO)IBA 09/2016 - 02/2016
2	Dihydroxyphenylalanine (Dopa)IBA 09/2015 - 02/2012
2	ProdrugsIBA 01/2011 - 05/2010
2	Nicotinic Receptors (Nicotinic Acetylcholine Receptor)IBA 08/2009 - 03/2009
2	Yohimbine (Yocon)IBA 11/2008 - 09/2008
2	Glucagon (Glukagon)FDA Link 11/2008 - 09/2008
2	Isoproterenol (Isoprenaline)FDA LinkGeneric 11/2008 - 09/2008
2	Epinephrine (Adrenaline)FDA LinkGeneric 09/2008 - 01/2003
2	Amino Acids FDA Link 12/2004 - 08/2003
2	Tyrosine 3-Monooxygenase (Tyrosine Hydroxylase)IBA 12/2004 - 03/2003
1	Clorgyline (Clorgiline)IBA 09/2016
1	3,4-dihydroxyphenylethanol (hydroxytyrosol)IBA 09/2016
1	Selegiline (E250)FDA LinkGeneric 09/2016
1	rasagiline (Azilect)FDA Link 09/2016
1	Aldehyde DehydrogenaseIBA 06/2015
1	Messenger RNA (mRNA)IBA 01/2015
1	AcidsIBA 06/2012
1	Protein AggregatesIBA 08/2011
1	fluorodopa F 18IBA 01/2010
1	AntibodiesIBA 03/2009
1	Trimethaphan (Trimetaphan)IBA 11/2008
1	Pentolinium Tartrate (Pentolonium Tartrate)FDA Link 11/2008
1	Edrophonium (Tensilon)FDA LinkGeneric 09/2008
1	Saline SolutionIBA 01/2008
1	arginine methyl esterIBA 01/2008
1	BuffersIBA 01/2008
1	Nitric Oxide Synthase (NO Synthase)IBA 01/2008
1	NG-Nitroarginine Methyl Ester (L-NAME)IBA 01/2008
1	Levodopa (L Dopa)FDA LinkGeneric 12/2005
1	N-Methyl-3,4-methylenedioxyamphetamine (MDMA)IBA 06/2005
1	Creatine Kinase (Creatine Phosphokinase)IBA 06/2005
1	Pharmaceutical PreparationsIBA 06/2005
1	Carvedilol (Coreg)FDA LinkGeneric 06/2005
1	Vesicular Monoamine Transport Proteins (Vesicular Monoamine Transporter)IBA 12/2004
1	GTP Cyclohydrolase (GTP Cyclohydrolase I)IBA 12/2004
1	catechol (pyrocatechol)IBA 12/2004
1	1- Methyl- 4- phenyl- 1,2,3,6- tetrahydropyridine (MPTP)IBA 09/2003
1	EnzymesIBA 08/2003
1	FludrocortisoneIBA 08/2003
1	Oxidopamine (6 Hydroxydopamine)IBA 03/2003

Therapy/Procedure

12	Sympathectomy (Sympathectomies) 01/2017 - 08/2002
11	Denervation 01/2017 - 09/2003
1	Injections 09/2003
1	Oral Administration 08/2003
1	Therapeutics 08/2003
1	Radiotherapy 07/2003
1	Drug Therapy (Chemotherapy) 07/2003